Osteoporosis is a condition that causes a thinning of the bones. This can result in vertebral compression fractures, deformity (kyphosis) and even death. Osteoporosis and related spine fractures are largely treatable and preventable with medications, calcium intake, and kyphoplasty or vertebroplasty surgery.


Causes of Osteoporosis

It is caused principally by the significant loss of bone mineral density (BMD). Early in life, more bone is laid down than is removed, and an individual’s peak bone mass is typically achieved by around age 30. After peak bone mass is reached, the remodeling process (the process of laying down new bone and removing old bone) takes away more bone than is replaced. Hence making the bones more prone to osteoporosis (and consequently to fracture).

Thus, the process of bone loss typically begins between one’s early to late thirties. Starting from about that age to the onset of menopause, women lose a certain amount of bone steadily every year, as follows:

  • Trabecular bone (the spongy bone inside the hard, cortical bone) is lost at a rate of about 1% per year
  • Cortical bone (the hard bone) is lost at a rate of about 0.5% per year

Estrogen plays an important part in maintaining bone strength because it helps keep bone remodeling (which is now taking away more bone than is added) rates low. There are two lines of cells for bone remodeling, the bone-eating cells (osteoclasts) and the bone-forming cells (osteoblasts). Without estrogen, the osteoclasts are favored and more bone is resorped (removed) than laid down, resulting in thinning of the bone.

Therefore, when women reach menopause and their estrogen levels decrease, the rate of bone loss increases to about 2% to 3% per year. After 8 to 10 years, the rate of bone loss returns to the previous rate of 1% and 0.5% per year, respectively


Depending on your location around the world and approval of the following drugs may come in handy :-

  • Osteoporosis medications that slow or stop bone resorption
    • Bisphosphonates
    • Calcitonin
    • Selective Estrogen Receptor Modulators, e.g., Raloxifene
    • Estrogen/hormone therapy
  • Osteoporosis medications that increase bone formation
    • Teriparatide, a parathyroid hormone